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Introduction Chronic obstructive pulmonary disease (COPD) has an estimated global prevalence of >200 million cases [1] and is the third leading cause of mortality worldwide [2]. The occurrence of an acute exacerbation of COPD (AE-COPD), characterized by worsening respiratory symptoms, represents a leading cause of hospitalization and is associated with reduced quality of life and death [3]. The most frequent cause of AE-COPD is infection [4].
Background The Standards for the Diagnosis and Treatment of Patients with COPD document 2004 updates the position papers on chronic obstructive pulmonary disease (COPD) published by the American Thoracic Society (ATS) and the European Respiratory Society (ERS) in 1995 1, 2. Both societies felt the need to update the previous documents due to the following. 1) The prevalence and overall importance of COPD as a health problem is increasing.
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