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Addition of an immunomodulator can reverse antibody formation and loss of response in patients treated with adalimumab
Anti-adalimumab antibodies (AAA) are associated with loss of clinical response (LOR). Addition of an immunomodulator has been shown to reverse immunogenicity and regain response with infliximab monotherapy. Similar data on adalimumab are lacking. To study the impact of immunomodulator addition on the emergence of AAA and LOR among adalimumab therapy patients.
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