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A. Dunbar

As seen in: British Pharmacological Society
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GS‐443902 concentrations in peripheral blood mononuclear cells and dried blood spots among pregnant and non‐pregnant women receiving remdesivir for COVID‐19 treatment - Dunbar - 2025 - British Journal of Clinical Pharmacology - Wiley Online Library

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By A. Dunbar, K. Baltrusaitis, D. Clarke, S. Nachman
| British Pharmacological Society
2 Background: Activation of remdesivir (RDV) has typically been assessed by measuring concentrations of GS-443902 (active triphosphate) in peripheral blood mononuclear cells (PBMC). We previously showed concentrations of RDV, and its major plasma metabolites were similar between pregnant and non-pregnant women with COVID-19, while those of GS-443902 in PBMC were ~50% lower in pregnancy.
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