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In the past years, synthetic approaches to phosphorus-substituted heterocycles have gained increasing interest [1]. The incorporation of a phosphorus motif into the target heterocyclic molecules can produce new attractive properties, which lead to a variety of applications in different fields [2]. An interesting illustration is provided by medicinal chemistry.
This study evaluates the efficacy of intraoperative neuromonitoring (IONM) with a pre-embolization lidocaine injection challenge (“provocative testing”) to minimize iatrogenic, irreversible nerve injury during embolization of peripheral AVMs.
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