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Aabha Sharma

As seen in: Nature, JD Supra, Lexology, Inferse
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Articles

Cellular and molecular basis of Pf Coronin function in artemisinin resistance in Plasmodium falciparum

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By Imran Ullah, Madeline A. Farringer, Anna Y. Burkhard, Erica Hathaway, Bailey C. Willett, Sara Shin, Aabha Sharma, River Mallick, Eva S. Istvan, Morgan Martin Verified, Jeffrey D. Dvorin, Daniel L. Hartl, Sarah Volkman, Selina Bopp, Sabrina Absalon, Malhar Khushu, Oliver Harrigan, Kairon L. Shao
| Nature Verified
Abstract Artemisinin combination therapies are central to malaria control, but their efficacy is threatened by the emergence of resistant Plasmodium falciparum strains. While the role of Pfkelch13 mutations is well established, mutations in Pfcoronin have also been implicated in treatment failure, revealing layers of resistance complexity. Here, we define the cellular mechanism of Pfcoronin‑mediated artemisinin resistance.
Open in Who Shared Issue with article?
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By Aabha Sharma
| Inferse
Open in Who Shared Issue with article?
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By Aabha Sharma
| Inferse
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