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Aayushma Lohani on Muck Rack

Aayushma Lohani

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Expanded proinflammatory CD4 T cells expressing toll like receptor 4 in trauma associated acute lung injury

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By Priyanka Hastak, Christopher Andersen, Phoebe Crammond, Chansavath Phetsouphanh, David van Bockel, Calum J. Walsh, Louise M Judd, Timothy P. Stinear, Raymond Louie, Frances Bass, Anthony Delaney, Naomi E Hammond, Balasubramanian Venkatesh, Simon R. Finfer, Nicodemus Tedla, Anthony D. Kelleher, Sarah C. Sasson, Zong-Hong Zhang, Aayushma Lohani, Swosti Shrestha
| Nature Verified
Abstract Acute lung injury (ALI) is characterised by hypoxia and inflammation that derives from diverse aetiologies. Delineating the molecular pathogeneses may identify treatable subgroups and inform clinical trials. Using a multi-omics approach, we analysed trauma-associated ALI (n = 9), COVID-19 ALI (n = 11), ICU controls (n = 13) using scRNA-seq, serum cytokine profiling, and bronchoalveolar lavage (BAL) microbiome analysis.
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