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Ababacar Diouf on Muck Rack

Ababacar Diouf

As seen in: Cell Reports Medicine
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Articles

A strain-transcending anti-AMA1 human monoclonal antibody neutralizes malaria parasites independent of direct RON2L receptor blockade

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By Palak Patel, Ababacar Diouf, Thayne H. Dickey, Wai Kwan Tang, Christine S. Hopp, Boubacar Traore, Carole Long, Kazutoyo Miura, Peter Crompton, Niraj Tolia
| Cell Reports Medicine Verified
Keywords AMA1 malaria blood-stage monoclonal antibody vaccine synergy Introduction Malaria is a life-threatening disease caused by Plasmodium parasites that are transmitted to humans by mosquitoes.1 Malaria poses a significant threat to almost half of the global population, with children under the age of five being the most vulnerable to this disease.1 Plasmodium falciparum, the deadliest malaria parasite, is responsible for nearly all malaria-related fatalities in sub-Saharan Africa and the...
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Antibodies from malaria-exposed Malians generally interact additively or synergistically with human vaccine-induced RH5 antibodies

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By Alex Huber, Alexandra C. Willcox, Ababacar Diouf
| Cell Reports Medicine Verified
Quantification and statistical analysis The following formula, specific for antibody combinations in GIA, was used in the current study: %GIA[A+B]=[1−(1−%GIAA100)∗(1−%GIAB100)]∗100 Predicted % inhibition values for antibody combinations were calculated using the formula for Bliss additivity, originally developed to assess the toxicity of poisons in combination.
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