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Articles by Abbey Geraghty
Antioxidant Poly(propylene sulfide) Nanoparticles Ameliorate Ischemia-Reperfusion Injury and Improve Porcine Kidney Function Post-Transplantation
Biological and Medical Applications of Materials and InterfacesOctober 15, 2025 John P.
Antioxidant Polysulfide Nanoparticles Ameliorate Ischemia-Reperfusion Injury and Improve Porcine Kidney Function Post-Transplantation
Abstract Ischemia-reperfusion injury (IRI) is a significant complication in kidney transplantation, often affecting the viability and function of organs. Normothermic machine perfusion (NMP) is a technique used to improve the condition of organs prior to transplantation. In this study, we show that incorporating antioxidant poly(propylene sulfide) nanoparticles (PPS-NPs) during cold-storage and NMP significantly enhances its efficacy in reducing IRI upon porcine kidney transplantation.
Polysulfide Nanoparticles Ameliorate Ischaemia Reperfusion Injury in Renal Transplantation and Improve Kidney Function Post-Transplantation
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Renal haemofiltration prevents metabolic acidosis and reduces inflammation during normothermic machine perfusion of the vascularised composite allograft - a preclinical study - Stone - - Artificial Organs - Wiley Online Library
MAIN TEXT John P Stone, orcid.org/0000-0001-9452-2843 The Ex-Vivo Research Centre, 3F66, Block 3, Alderley Park, Nether Alderley, Cheshire, SK10 4TG The Ex-Vivo Lab, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK Both authors contributed equally Search for more papers by this author Kavit R Amin, The Ex-Vivo Research...
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