Abbigael Harthorn

1 Introduction B7-H3, also known as CD276, is an important immune checkpoint modulator of T-cell function (Picarda et al. 2016). It is also a tumor vasculature biomarker overexpressed in a variety of cancers, including clear cell renal cell carcinoma (Crispen et al. 2008), cutaneous melanoma (Wang et al. 2013), diffuse intrinsic pontine glioma (Zhou et al. 2013), hypopharyngeal squamous cell carcinoma (Katayama et al. 2011), non-small cell lung cancer (Sun et al. 2006), ovarian cancer (Lutz et al.

Abstract Protein-small molecule hybrids are structures that have the potential to combine the inhibitory properties of small molecules and the specificities of binding proteins. However, achieving such synergies is a substantial engineering challenge, with fundamental principles yet to be elucidated.