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Articles by Abdel Alli
Targeted lipidomics between hPheo1 and SDHB KD cells reveal changes in bioactive lipids and PKC with polyamine pathway inhibition
1 INTRODUCTION Pheochromocytomas (PCCs) and paragangliomas (PGLs) (PCPG's) are rare neuroendocrine tumors (Juhlin, 2021). However, PCPG patients with mutations in the succinate dehydrogenase subunit B (SDHB) gene have a greater incidence of metastatic disease. Moreover, metastatic PCPG's usually present as advanced tumors with limited treatment options.
A benchtop bioreactor to impart coarctation-induced deformation and assess mechanisms of endothelial dysfunction
Abstract Hypertension (HTN) is common with coarctation of the aorta (CoA), a common congenital cardiovascular defect. Coarctation-induced mechanical stimuli can drive remodeling in the proximal aorta, resulting in stiffening and HTN. Natriuretic peptide receptor C (NPRC) expression is downregulated in proximal aortas of hypertensive CoA patients, and preclinical models show endothelial NPRC decreases with increasing coarctation severity.
Small Extracellular Vesicles with a High Sphingomyelin Content Isolated from Hypertensive Diabetic db/db Mice Inhibits Calcium Mobilization and Augments Amiloride-Sensitive Epithelial Sodium Channel Activity
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Extracellular Vesicles: Investigating the Pathophysiology of Diabetes-Associated Hypertension and Diabetic Nephropathy
1. Introduction Extracellular vesicles (EVs) are a heterogeneous population of vesicles that are generally classified according to their size and biogenesis. Exosomes are the smallest type of EV and originate from the formation of multivesicular bodes [1]. Microvesicles (previously called microparticles) are generally less than 1000 nm in diameter and originate from the budding of the plasma membrane [1].
Augmentation of Cathepsin Isoforms in Diabetic db/db Mouse Kidneys Is Associated with an Increase in Renal MARCKS Expression and Proteolysis
Abstract : The expression of the myristoylated alanine-rich C-kinase substrate (MARCKS) family of proteins in the kidneys plays an important role in the regulation of the renal epithelial sodium channel (ENaC) and hence overall blood pressure regulation. The function of MARCKS is regulated by post-translational modifications including myristoylation, phosphorylation, and proteolysis.
Modulation of calreticulin expression reveals a novel exosome-mediated mechanism of Z variant α1-antitrypsin disposal
Nazli Khodayari‡, Regina Oshins‡, Abdel A. Alli§, Kubra M. Tuna§, L.
Modulation of calreticulin expression reveals a novel exosome mediated mechanism of Z variant alpha-1 antitrypsin disposal
Nazli Khodayari1, Regina Oshins2, Abdel A Alli3, Kubra M Tuna2, L.
The Lectin-like Domain of TNF Increases ENaC Open Probability Through a Novel Site at the Interface Between the Second Transmembrane and C-Terminal Domains of the α Subunit
Regulation of the epithelial sodium channel (ENaC), which regulates fluid homeostasis and blood pressure, is complex and remains incompletely understood. The TIP peptide, a mimic of the lectin-like domain of TNF, activates ENaC, by binding to glycosylated residues in the extracellular loop of ENaC-α, as well as to a hitherto uncharacterized internal site.
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