Abdol R. Hajipour

Pd/Cu-free Magnetic Cobalt Catalyst for C-N cross Coupling Reactions: Synthesis of Abemaciclib and Fedratinib Herein, the synthesis of a nano-catalyst system comprising magnetic nanoparticles as core and edible natural ligands bearings functional groups for supporting the cobalt species was accomplished. Subsequent to characterization, its efficiency was investigated for C-N cross-coupling reactions deploying assorted derivatives of amines and aryl halides.

The chitosan (CS) is a porous self-standing nanofibrillar microspheres which can be used as a metal carrier. Amino-groups on CS enable to modulation of cobalt coordination using safe organic ligand (methyl salicylate). This catalyst efficiently promote Heck cross-coupling of a large library of functional substrates under mild and sustainable conditions (polyethylene glycol as solvent at 80 °C in short time (1 h)).