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Abdukahar Kiram on Muck Rack

Abdukahar Kiram

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Articles

BRD4 directs myofiber identity and metabolic adaptation through CHD4 cooperation

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By Zheng Zhou, Lin Liu, Zhisheng Xu, Danxia Zhou, Anqi Liu, Jiachen Yuan, Qiqi Guo, Yujing Yin, Wanping Sun, Liwei Xiao, Cheng Lv, Abdukahar Kiram, Likun Yang, Yuhuan Jia, Lu Ke, Lei Fang, Weiqin Li, Tingting Fu, Zhenji Gan, Gonghao Shen
| Nature Verified
Abstract Skeletal muscle fiber-type composition is key determinant of systemic metabolism and health. However, how fiber-type-specific gene expression patterns are established and maintained to specify myofiber identity remains unclear. Here we show that BRD4 is a crucial regulator for muscle fiber identity and metabolism. In humans, BRD4 expression correlates with muscle contractile properties, and is notably altered in individuals with obesity.
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