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Abdullah Aldehaiman on Muck Rack

Abdullah Aldehaiman

As seen in: BioRxiv
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Functional selection in SH3-mediated activation of the PI3 kinase

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By Safia S Aljedani, Abdullah Aldehaiman, Anandsukeerthi Sandholu, Siba Alharb
| BioRxiv
Abstract The phosphoinositide-3 kinase (PI3K), a heterodimeric enzyme, plays a pivotal role in cellular metabolism and survival. Its deregulation is associated with major human diseases, particularly cancer. The p85 regulatory subunit of PI3K binds to the catalytic p110 subunit via its C-terminal domains, stabilizing it in an inhibited state. Certain Src homology 3 (SH3) domains can activate p110 by binding to the proline-rich (PR) 1 motif located at the N-terminus of p85.
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