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Articles

Role of DNA methylation in expression control of the IKZF3-GSDMA region in human epithelial cells

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By Hamid-Reza Kohan-Ghadr, Sanny Moussette, Abeer Al Tuwaijri, Samar Elzein
| PLOS
Chromosomal region 17q12-q21 is associated with asthma and harbors regulatory polymorphisms that influence expression levels of all five protein-coding genes in the region: IKAROS family zinc finger 3 (Aiolos) (IKZF3), zona pellucida binding protein 2 (ZPBP2), ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3), and gasdermins A and B (GSDMA, GSDMB). Furthermore, DNA methylation in this region has been implicated as a potential modifier of the genetic risk of asthma development.
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