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Abigail R. Barber on Muck Rack

Abigail R. Barber

As seen in: Science Magazine, BioRxiv, Journal of Nuclear Medicine
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Articles

Imaging xCT with Immuno-PET in Therapy-Resistant Non–Small Cell Lung Cancer

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By Abigail R. Barber, Richard Edwards, Sofia Dos Santos
| Journal of Nuclear Medicine Verified
MATERALS AND METHODS Additional methods are provided in the supplemental materials, available at http://jnm.snmjournals.org. Lysine residues on HM30, HM34, and control human IgG1 (BioXcell) were labeled using p-SCN-Bn-deferoxamine (DFO; B-705; Macrocyclics). A previously published 2-step method, consisting of chelator–antibody conjugation and subsequent radiolabeling, was used (Supplemental Fig. 1) (23).
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Imaging the master regulator of the antioxidant response in non-small cell lung cancer with positron emission tomography

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By Hannah E Greenwood, Richard Edwards, Will Tyrrell, Abigail R. Barber
| BioRxiv
Abstract Mutations in the NRF2-KEAP1 pathway are common in non-small cell lung cancer (NSCLC) and confer broad-spectrum therapeutic resistance, leading to poor outcomes. The cystine/glutamate antiporter, system xc−, is one of the >200 cytoprotective proteins controlled by NRF2, which can be non-invasively imaged by (S)-4-(3-18F-fluoropropyl)-ʟ-glutamate ([18F]FSPG) positron emission tomography (PET).
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