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Articles by Abin Abraham
Placental Vascular Pathology Associated with Congenital Lymphocytic Choriomeningitis Virus Infection, Philadelphia, Pennsylvania, USA
Lymphocytic choriomeningitis virus (LCMV) is an underappreciated congenital pathogen carried by rodents (1). Congenital LCMV infection is associated with pathognomonic chorioretinitis and a variety of neurologic malformations (2). A case of fetal hydrops caused by congenital LCMV also has been reported (3). In a large maternal seroprevalence study, we found that 2.5% of a random sample of 1,000 women who gave birth in Philadelphia, Pennsylvania, USA, were LCMV IgG–positive (4).
Prevalence of Hearing Loss in Type 2 Diabetes Mellitus and Its Association with Severity of Diabetic Neuropathy and Glycemic Control
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Mosaic patterns of selection in genomic regions associated with diverse human traits
Alzheimer’s disease associated genomic regions lack enrichment for evolutionary signatures The GWASs of nearly all traits in the BOLT-LMM set had enrichment for diverse genomic signatures of selection. In contrast, we observed that genomic regions associated with late-onset Alzheimer’s disease exhibited no significant enrichment for any evolutionary measure (Fig 4). This result held across five published GWASs of late-onset Alzheimer’s disease.
Mosaic patterns of selection in genomic regions associated with diverse human traits
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Complex diseases through the lens of natural selection
If evolution leads to adaptation to our environments, then why do we still get diseases? In many cases, disease is the price we pay for evolutionary innovations. If you like having a body made up of multiple cells, then you run the risk of getting cancer. That big brain you’ve got might lead to the development of schizophrenia. And because environments often change faster than we can evolve, evolutionary adaptations that were once useful may be obsolete or even harmful in the present day.
Sexually Antagonistic Selection on Genetic Variation is Rare in Humans
New Results doi: https://doi.org/10.1101/2020.03.26.009670 Abstract Sex and sexual differentiation are ubiquitous across the tree of life. Because females and males often have substantially different functional requirements, we would expect selection to differ between the sexes. Recent studies in diverse species, including humans, suggest sexually antagonistic viability selection creates allele frequency differences between the sexes at many different loci.
Accounting for diverse evolutionary forces reveals the mosaic nature of selection on genomic regions associated with human preterm birth
ABSTRACT Human pregnancy requires the coordinated function of multiple tissues in both mother and fetus and has evolved in concert with major human adaptations. As a result, pregnancy-associated phenotypes and related disorders are genetically complex and have likely been sculpted by diverse evolutionary forces.
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