Antonis Rokas on Muck Rack

Antonis Rokas

  • Cornelius Vanderbilt Chair in Biological Sciences Professor of Biological Sciences, Professor of Bio, Vanderbilt University
Nashville
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The Laboratory of Antonis Rokas at Vanderbilt University. Tweets should be interpreted as bookmarks, not as endorsements. All opinions are Antonis'.
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Articles

Large-scale multi-omics profiling reveals environmental and evolutionary drivers of fungal phylogeographic and metabolic diversity

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By Huali Xie, Jie Hu, Xiulan Zhao, Jianwei Chen, Xiaofeng Yue, Changhao Zhou, Jorge C. Navarro-Munoz, Jun Jiang, Xiaoqian Tang, Fang Zhao, E. Anne Hatmaker, Antonis Rokas, Amelia E. Barber, Milton T. Drott, Nancy P. Keller, Qi Zhang, Marnix H. Medema, Peiwu Li, Justin J. J. van der Hooft
| Nature Verified
Abstract Chemical innovation is essential for fungi to adapt to ever-changing ecological environments. However, the environmental and evolutionary drivers of fungal metabolic differentiation remain ambiguous. Here, we show the phylogeographic diversity of 1052 Aspergillus flavus strains across four continents, as conducted through phylogenetic and biogeographical analysis, including 544 newly sequenced strains from China.
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Ancient co-option of LTR retrotransposons as yeast centromeres - Nature

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By Max Haase, Luciana Lazar-Stefanita, Lyam Baudry, Aleksandra Wudzinska, Xiaofan Zhou, Antonis Rokas, Chris Todd Hittinger, Boris Pfander, Andrea Musacchio, Jef Boeke
| Nature Verified
Abstract Centromeres ensure accurate chromosome segregation, yet their DNA evolves rapidly across eukaryotes leaving the origins of new centromere architectures unclear1,2,3,4. The brewer’s yeast Saccharomyces cerevisiae exemplifies this long-standing puzzle. Its centromeres shifted ancestrally from large, repeat-rich, epigenetically specified forms to the compact, genetically defined ‘point’ centromeres1,5. How this transition occurred has remained unresolved6.
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Discovery of additional ancient genome duplications in yeasts

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By Kyle David, Linda C. Horianopoulos, Carla Milena Goncalves, Carla Oliveira Gonçalves, Jacob L. Steenwyk, Ana Pontes, Paula Gonçalves, Chris Todd Hittinger, Matt Pennell, Antonis Rokas
| Cell Press Verified
Keywords whole-genome duplication yeasts polyploidy convergent evolution Get full text access Log in, subscribe or purchase for full access. References 1. Otto, S.P. The evolutionary consequences of polyploidy Cell. 2007; 131:452-462 2. Van de Peer, Y. ∙ Mizrachi, E. ∙ Marchal, K. The evolutionary significance of polyploidy Nat. Rev. Genet. 2017; 18:411-424 3. Dehal, P. ∙ Boore, J.L. Two rounds of whole genome duplication in the ancestral vertebrate PLOS Biol. 2005; 3:e314 4. Ohno, S.
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