Absar Talat on Muck Rack

Absar Talat

As seen in: Nature
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Sequestration of the phagocyte metabolite itaconate by Pseudomonas aeruginosa RpoN promotes successful pulmonary infection - Nature Communications

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By Zihua Liu, Ying-Tsun Chen, Jake Miller, Lindsey C Florek, Lars E.P. Dietrich, Chu Wang, Ian Lewis, Sebastian Herrero Riquelme, Sebastián A. Riquelme, Absar Talat, Griffin Gowdy
| Nature
Abstract Inhaled opportunistic pathogens such as Pseudomonas aeruginosa actively modify gene expression to meet the challenges of a new environment. In the infected airway the bacteria must respond to the immunometabolite itaconate, which is abundantly produced by macrophages and has anti-inflammatory and anti-oxidant functions that protect the host from airway damage and causes toxicity to bacteria.
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