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AC Williams

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Articles

Targeting LGR5 in Colorectal Cancer: therapeutic gold or too plastic?

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By RG Morgan, E Mortensson, AC Williams
| Nature Verified
Given its well documented role in potentiating Wnt/β-catenin signalling (and the wider involvement of this pathway in CRC pathology), it is not surprising that many reports have indicated a pro-oncogenic role for LGR5 in CRC. These include studies that have examined LGR5 expression in CRC patient tissue, its prognostic value, and its functional significance in experimental models.
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