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Ad F. Roffel on Muck Rack

Ad F. Roffel

As seen in: Drug Metabolism and Disposition (ASPET), TechTrends
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Articles

Absorption, metabolism and excretion of 14C-emvododstat following repeat daily oral dose administration in human volunteers using a combination of microtracer radioactivity and high radioactivity doses

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By Jiyuan Ma, Oscar Laskin, Wouter Vaes, Ad F. Roffel
| Drug Metabolism and Disposition (ASPET)
Abstract Emvododstat is a potent inhibitor of dihydroorotate dehydrogenase and is now in clinical development for the treatment of COVID-19 and acute myeloid leukemia. Since the metabolism and pharmacokinetics of emvododstat in humans is time‑dependent, a repeat dose study design using a combination of microtracer radioactivity and high radioactivity doses was employed to evaluate the metabolism and excretion of emvododstat near steady state.
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Absorption, Metabolism, and Excretion of 14C-Emvododstat Following Repeat Daily Oral Dose Administration in Human Volunteers Using a Combination of Microtracer Radioactivity and High-Radioactivity Doses

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By Jiyuan Ma, Oscar Laskin, Ad F. Roffel, Wouter Vaes
| Drug Metabolism and Disposition (ASPET)
Study Design and Sample Collection The human AME study was conducted in accordance with the Declaration of Helsinki and the International Council for Harmonization Good Clinical Practice. An independent ethics committee reviewed and approved the clinical study protocol, any clinical study protocol amendments, subject information sheets, written informed consent forms, and other relevant documentation.
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