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Ad Verhagen on Muck Rack

Ad Verhagen

As seen in: Nature, Lung Cancer
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Articles

Occult lymph node metastases in clinical N0/N1 NSCLC; A single center in-depth analysis

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By Ad Verhagen, Ferhat Beyaz, Roel L.J. Verhoeven, Olga C.J. Schuurbiers
| Lung Cancer Verified
Highlights • Unforeseen upstaging in patients clinically staged as N0 occurs in 23.1 % of cases. • Nodal regions not accessible by current staging modalities are frequently affected. • In 50 % of occult nodal metastases, primary tumors had a size ≤3 cm (T1a-T1c). Abstract Objectives Lymph node staging in patients with non-small cell lung cancer is crucial for determining prognosis and treatment.
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Randomised phase 3 study of adjuvant chemotherapy with or without nadroparin in patients with completely resected non-small-cell lung cancer: the NVALT-8 study

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By Theo Klinkenberg, Joachim GJV Aerts, Bonne Biesma, Ad Verhagen
| Nature Verified
Abstract Background Retrospective studies suggest that low molecular weight heparin may delay the development of metastasis in patients with resected NSCLC. Methods Multicentre phase 3 study with patients with completely resected NSCLC who were randomised after surgery to receive chemotherapy with or without nadroparin. The main exclusion criteria were R1/2 and wedge/segmental resection. FDG-PET was required. The primary endpoint was recurrence-free survival (RFS).
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