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Ada Nursel Topçu

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Articles

Reduced inhibition, bursting, and accelerated oscillations drive early hippocampal hyperactivity in Alzheimer’s disease in vivo

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By Soraya Meftah, Sungmin Kang, Mingshan Liu, Xingran Wang, Long Wan, Conor Mullin, Lida Zoupi, Jian Gan, Ada Nursel Topçu, Maialen Martin Abad
| Nature Verified
Abstract ‘Early hippocampal hyperactivity’ is well-documented in Alzheimer’s disease (AD), yet its mechanisms in vivo before amyloid-β plaque deposition at the levels of synaptic transmission and neural oscillations remain unclear. Here, we perform in vivo high-resolution patch-clamp and high-throughput probe recordings in the hippocampus of amyloidopathy mice before plaque deposition.
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