Adán Herrera Guerrero

Abstract INTRODUCTION RESULTS DISCUSSION METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Fully capturing the heterogeneity of biological processes remains a central challenge, as conventional confocal microscopy typically surveys large ensembles of molecules within a small volume.

Introduction Infertility is a major health problem worldwide and its incidence is increasing (Rutstein and Shah, 2004; Pereira and Sousa, 2023; WHO, 2023). It is defined as a failure to achieve pregnancy after 12 months or more of regular unprotected sexual intercourse (Zegers-Hochschild et al., 2009). 20%–50% of infertility cases can been attributed to male factors (Kumar and Singh, 2015) and several causes are known to contribute to male infertility.

We have reduced the emphasis on mechanical by presenting always an alternative interpretation highlighting what fits or not the experimental data. Explanations to reviewers are showed below. We have made a great effort on this point as reflected by re-writing extensively the text (all text highlighted in yellow means new text). This point is now explained in page 24.