Addiction Neuroscience

1 INTRODUCTION Frontloading is an alcohol drinking pattern where intake is skewed towards the onset of access which results in intoxication.1 As discussed in our recent review,1 we theorized that alcohol frontloading is driven by the rewarding effects of alcohol and, importantly, alcohol frontloading may predict long-term maladaptive alcohol drinking patterns leading to the development of alcohol use disorder (AUD).

Introduction The concept of “sugar addiction” and the classification of sugar as a substance of abuse are still debated. There is, however, increasing evidence of overlap in the brain circuitry and molecular signaling pathways involved in sugar consumption and drug abuse (for recent review see Jacques et al., 2019). Humans consume sugar and food to regulate homeostatic energy balance, but also for pleasure and comfort.