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Keywords extracellular matrix MT1-MMP invadopodia mTORC1 TFEB triple-negative breast cancer tumor invasion patient-derived xenograft mTOR inhibitors Introduction The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway is often hyperactivated in breast cancers (BCs), including in triple-negative BCs (TNBCs), providing therapeutical options for this poor prognosis subtype, which is immune to endocrine therapy.1,2 Under nutrient-replete conditions,...
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