Adhithiya Charli on Muck Rack

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Mitochondrial Stress Disassembles Nuclear Architecture through Proteolytic Activation of PKCδ and Lamin B1 Phosphorylation in Neuronal Cells: Implications for Pathogenesis of Age-related Neurodegenerative Diseases

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By Jie Luo, Bharathi Palanisamy, Emir Malovic, Adhithiya Charli
| biorxiv.org
Abstract Mitochondrial dysfunction and oxidative stress are hallmarks of pathophysiological processes in age-related neurodegenerative diseases including Parkinson′s, Alzheimer′s and Huntington′s diseases. Neuronal cells are highly vulnerable to mitochondrial stress, however, the cellular and molecular mechanisms underlying the enhanced vulnerability are not well understood.
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