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Adiel Richter Levin on Muck Rack

Adiel Richter Levin

As seen in: Royal Society of Chemistry
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Articles

Selective binding of c-MYC G-quadruplex caged in a dsDNA by a hemopeptide

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By Eyal Golub, Leen Massalha, Adiel Richter Levin, Nurit Adiram
| Royal Society of Chemistry Verified
Selective binding of c-MYC G-quadruplex caged in a dsDNA by a hemopeptide Achieving selectivity of ligands towards guanine-quadruplexes (GQs) is a prerequisite for their implementation in a cellular environment. Herein, we explored the binding properties of the hemopeptide microperoxidase-11 (MP-11) towards different GQs and configurations. The peptide-heme interplay promoted selective ligand binding for c-MYC GQ by uncaging and binding it from duplex DNA.
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