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Adilai Maihemuti on Muck Rack

Adilai Maihemuti

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Articles

Fluorofenidone ameliorates pressure overload-induced heart failure by stabilizing SERCA2a in male mice

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By Quan Liu, Huayang Li, Jiantao Chen, Qiushi Ren, Li Luo, Zeyu Li, Suiqing Huang, Zhuoming Zhou, Kaizheng Liu, Jinyu Pan, Kangni Feng, Mengya Liang, Zhongkai Wu, Tongxin Chu, Liqun Shang, Adilai Maihemuti, Zhilin Miao
| Nature Verified
Abstract Reduced expression and activity of cardiac sarco/endoplasmic reticulum Ca2+-ATPase 2a (SERCA2a), causing intracellular calcium dyshomeostasis, are regarded as hallmarks of heart failure (HF). However, effective SERCA2a-targeted therapies for HF treatment have not been identified. Here, we show that fluorofenidone, previously reported to enhance cell shortening, contraction and relaxation of cardiomyocytes by nearly 100%, prevents the progression of pressure overload-induced HF.
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