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Integrated Multiomics Enabled by Sequential Extraction for Comprehensive Molecular Profiling of Small Extracellular Vesicles Click to copy article link Article link copied!
In this study, we developed a multiomics platform, combining LC-MS-based proteomics, lipidomics, and metabolomics to characterize the molecular composition of sEVs. We demonstrated this platform using sEVs isolated from MDA cells using UC and then evaluated its clinical applicability using plasma-derived sEVs isolated by SECUF, PPT, and UC. These methods were selected because they represent three widely used but mechanistically distinct strategies for sEV isolation.
Australian Open: Aryna Sabalenka and Iga Swiatek advance to 3rd round
Tennis players Aryna Sabalenka and Iga Swiatek advanced to the third round of the Australian Open by defeating Wang Xinyu and Rebecca Peterson, respectively. Meanwhile, Sam Stosur’s 69th and final appearance in a Grand Slam singles draw ended with a 6-2, 6-2 loss in the second round.
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