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Aditi Sai Marella on Muck Rack

Aditi Sai Marella

As seen in: Nature
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Systems genetic dissection of brain gene expression reveals excitotoxic mechanisms of Alzheimer’s disease - Molecular Psychiatry

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By Pinghan Zhao, Omar El Fadel, Anh Le, Carl Grant Mangleburg, Justin S Dhindsa, Timothy Wu, Jinghan Zhao, Meichen Huang, Bismark Kojo Amoh, Yarong Li, Nicholas T. Seyfried, Allan Levey, Zhandong Liu, Ismael Al-Ramahi, Juan Botas, Joshua M. Shulman, Aditi Sai Marella
| Nature Verified
Abstract Gene expression changes likely mediate the impact of Alzheimer’s disease (AD) neuropathology on cognition, but there are challenges to resolve the proximal causal pathways from postmortem brain transcriptome profiles which lack temporal resolution and are further confounded by mixed pathologies. Here, we functionally dissect 30 AD-associated human brain gene co-expression modules using fruit fly (Drosophila melanogaster) models.
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