Adrián de Rus-Moreno on Muck Rack

Adrián de Rus-Moreno

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Insights into the functional coordination of LigD and Ku in bacterial nonhomologous end joining

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By Alicia del Prado, Iza Bienkowska, Ana de Ory, Miguel de Vega, Amalia Buitrago, Adrián de Rus-Moreno, Silvia Díaz-Arco
| Nature Verified
Abstract Nonhomologous end joining (NHEJ) is a DNA repair pathway that directly ligates double-strand breaks (DSBs) and operates without a homologous template. In Bacillus subtilis, this process involves two core proteins: the Ku homodimer (KuBs) and LigD (LigDBs). The ring-shaped KuBs homodimer binds DNA ends, promotes their synapsis, and recruits LigDBs. LigDBs is a multifunctional enzyme featuring an N-terminal ligase domain (LigDom) and a C-terminal polymerization domain (PolDom).
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