Adrián González-Pinar on Muck Rack

Adrián González-Pinar

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Articles

Exploring How Cytoskeleton Dynamics Tunes T Cell Activation at the Immunological Synapse

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By Alvaro Gomez-Moron, Carlos Carrasco-Padilla, Pedro Roda-Navarro, Adrián González-Pinar
| Wiley Online Library Verified
1 Introduction During antigen-presenting cell (APC) recognition, initial signals through the T cell receptor (TCR) drive the formation of an actin-dependent lamellipodium over the APC interface. This facilitates integrin-mediated adhesion, further engagement of TCR–pMHC complexes, and triggering of early TCR signaling events.
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