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Gut enteroendocrine cell activation using a combination of GPR119 and GPR40 agonists results in synergistic hormone secretion in mice and humans

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By Iyassu Sebhat, Shuqin Zheng, Robert J. Lovelett, Xiaodong Yang, Victoria Dunn, Adrian Heilbut, Nicole Nicholas, Bryan Chan, JiaJun Liu, Ann Weber, Brett Lauring, Monika J.M. Murphy, Maja Engelstoft, Daniel Kosinski, John Whang, Maximilian G. Lombardo, Giuseppe Terracina, Molly Leitner, Matthew J. Consolati, Gregory Poterewicz, Annemarie Vance, Nancy Thornberry, Shirly Pinto
| Cell Metabolism Verified
Keywords bariatric surgery GPR40 GPR119 enteroendocrine cells gut enteroids gut peptides GLP-1 PYY CCK single-cell sequencing weight loss glucose control obesity Get full text access Log in, subscribe or purchase for full access. References 1. Zheng, D. ∙ Liwinski, T. ∙ Elinav, E. Interaction between microbiota and immunity in health and disease Cell Res. 2020; 30:492-506 2. Williams, E.K. ∙ Chang, R.B. ∙ Strochlic, D.E. ... Sensory Neurons that Detect Stretch and Nutrients in the Digestive System Cell.
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