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Adriana Alexandre S

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Articles

First human whole-body biodistribution and dosimetry analysis of [18F]LW223, a novel TSPO PET radiotracer

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By Adriana Alexandre S
| gla.ac.uk
Khaing, P. H. et al. (2026) First human whole-body biodistribution and dosimetry analysis of [18F]LW223, a novel TSPO PET radiotracer. European Journal of Nuclear Medicine and Molecular Imaging, (doi: 10.1007/s00259-025-07722-0) (PMID:41518399) (Early Online Publication) Text 376946.pdf - Published Version Available under License Creative Commons Attribution.
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First human whole-body biodistribution and dosimetry analysis of [ 18 F]LW223, a novel TSPO PET radiotracer

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By Adriana Alexandre S, Edinburgh Preclinical Imaging
| TechTrends
Radiochemistry LW223 precursor, (R)−3-chloromethyl-(N-sec-butyl)-N-methyl-4-phenylquinoline-2-carboxamide was prepared in eight steps from aniline and diethyloxalpropionate as previously described [10]. The general approach involved initial synthesis of the 4-hydroxyquinoline core, a Suzuki-Miyaura cross-coupling reaction to incorporate the phenyl moiety, side-chain amide construction and a Wohl-Ziegler halogenation as the key steps.
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