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Advaitha Madireddy

As seen in: Nature
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Articles

Endogenous and environmental factors that induce DNA replication defects and genomic instability in ER-negative heterozygous BRCA1 cells

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By Madhura Deshpande, Theodore Paniza, Rebecca Brown, Nitya Patel, Advaitha Madireddy, Zev Rosenwaks, Jeannine Gerhardt, Kate Heslin
| Nature Verified
Abstract Carriers with a germline mutation in the BRCA1 gene have an increased lifetime risk of breast and ovarian cancer and other malignancies. Cancer initiation is linked to mutagenesis and loss of heterozygosity (LOH) in BRCA1 carriers. Approximately 70% of BRCA1-associated breast cancers are triple negative (TNBC; progesterone (PR), HER2, estrogen receptor (ER)-negative), which were reported to develop from ER/PR-negative luminal progenitor cells.
Open in Who Shared Issue with article?
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By Jeannine Gerhardt, Andrés Aguilera, Advaitha Madireddy, Settapong T. Kosiyatrakul, Rebecca A. Boisvert, Emilia Herrera-Moyano, María L. García-Rubio, Elizabeth A. Vuono, Nichole Owen, Zi Yan, Susan Olson, Niall G. Howlett, Carl L. Schildkraut
| secure.jbs.elsevierhealth.com
Open in Who Shared Issue with article?
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