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Aerken Maolake on Muck Rack

Aerken Maolake

As seen in: Frontiers, BioRxiv
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Articles

Diagnostic accuracy of PSA derivatives for prostate cancer in patients with low prostate-specific antigen levels

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By Aerken Maolake, Jiuzhi Li, Aihemaiti Kadeer, Aihemaiti Aimaier, Mukadaisi Abuduwaili, Zecheng Ni
| Frontiers
BRIEF RESEARCH REPORT article Volume 15 - 2025 | https://doi.org/10.3389/fonc.2025.1602134 Introduction Prostate cancer (PCa) is the second most prevalent malignancy among men globally and a leading contributor to cancer-related morbidity and mortality (1).
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Androgen deprivation triggers a cytokine signaling switch to induce immune suppression and prostate cancer recurrence

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By Kai Sha, Shalini Singh Verified, Renyaun Zhang, Aerken Maolake
| BioRxiv
Abstract Androgen deprivation therapy (ADT) is an effective but not curative treatment for advanced and recurrent prostate cancer (PC). We investigated the mechanisms controlling the response to androgen-deprivation by surgical castration in genetically-engineered mouse models (GEMM) of PC, using high frequency ultrasound imaging to rigorously measure tumor volume. Castration initially causes almost all tumors to shrink in volume, but many tumors subsequently recur within 5-10 weeks.
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