Aeshah AlAzmi

1. Introduction Despite the long history of vancomycin use, many concerns remain about which dosing strategy is best to maximize bactericidal action and avoid toxicity [1]. The PK/PD parameter for therapeutic drug monitoring (TDM) that best describes the safety and efficacy of vancomycin is the ratio of the area under the curve over a 24 h period to the minimum inhibitory concentration (AUC0–24/MIC) [2,3]. Considering a MIC ≤ 1 mg/L, recommendations suggest a target AUC0–24 of 400–600 mg·h/L [4].