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Afiya Poindexter

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Articles

Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants

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By Shixin Ma, Léa Meneu, Hongbo Liu, Amin Abedini, Penn Medicine Biobank, Marylyn D. Ritchie, JoEllen Weaver, Nawar Naseer, Giorgio Sirugo, Yi-An Ko, Meghan Livingstone, Afiya Poindexter, Kyle P. Nerz, Fred Vadivieso, Stephanie DerOhannessian, Teo Tran, Julia Stepha
| Science Magazine Verified
Editor’s summary Kidney disease due to a variety of underlying conditions is quite common and contributes greatly to patient complications, healthcare costs, and mortality. To help address this problem in a comprehensive way, Liu et al. compiled a massive resource consisting of genetic data on more than 2 million human patients and detailed examination of the kidneys for hundreds of individuals, with a subset studied at single-cell precision.
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