Aging-Related Diseases

1 Introduction The lung is a highly complex organ with multiple cell types, intricate structures and specialised functions. Human induced pluripotent stem cells (iPSCs)-derived three-dimensional (3D) lung organoids offer substantial potential for investigating human lung development and pathologies.

Disclosure Requests for further information and resources should be directed to and will be fulfilled by the lead contact, Binbin Lai (laib@bjmu.edu.cn). Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement All processed data generated in this study, including single-cell expression matrices, the integrated .h5ad object, and donor metadata, have been deposited in Figshare under DOI: https://doi.org/10.6084/m9.figshare.30498725.

Abstract Introduction: Acquired resistance to platinum-taxane chemotherapy is a major cause of treatment failure in ovarian cancer (OC). In vitro cell models are indispensable tools for investigating chemoresistance mechanisms, and the establishment of new resistant cell models contributes to a more comprehensive understanding of these mechanisms. Currently, syngeneic mouse cell models remain scarce.