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Proteomic analysis of tissue-derived extracellular vesicles shows region-specific molecular changes in a rat model of takotsubo syndrome

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By Azra Miljanovic, Karin Ekström, Rossella Crescitelli, Ahmed Elmahdy, Annika Thorsell, Roger Olofsson Bagge, Björn Redfors, Elmir Omerovic, Ermir Zulfaj, Amirali Nejat, Mana Kalani
| Nature Verified
Abstract Takotsubo syndrome (TS) is characterized by transient regional wall motion abnormalities (RWMA) of the heart following stress. Extracellular vesicles (EVs) play a significant role in cellular communication and disease pathophysiology, but remain unexplored in TS. Using a high-fidelity rat model of TS induced by isoprenaline infusion (n = 16), we isolated EVs from the tissue of affected apical and unaffected basal segments of the left ventricle at 24 h post-induction.
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