Ai-Hua Jin on Muck Rack

Ai-Hua Jin

As seen in: Color Research & Application
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Conotoxin Φ-MiXXVIIA from the new superfamily G2 employs a novel cysteine framework that mimics granulin and displays anti-apoptotic activity

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By Zoltan Dekan, David Wilson , Irina Vetter, Richard Lewis, Ai-Hua Jin, Michael J Smout, Sébastien Dutertre, Alex Loukas, Norelle L Daly, Paul Francis Alewood
| Color Research & Application
Conotoxins are a large family of disulfide-rich peptides that contain unique cysteine frameworks that target a broad range of ion channels and receptors. We recently discovered the 33-residue conotoxin ?-MiXXVIIA from Conus miles with a novel cysteine framework comprising three consecutive cysteine residues and four disulfide bonds. Regioselective chemical synthesis helped decipher the disulfide bond connectivity and the structure of ?-MiXXVIIA was determined by NMR spectroscopy.
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