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Aida Amador-Álvarez on Muck Rack

Aida Amador-Álvarez

As seen in: MDPI, BioRxiv
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Articles

Rho GTPases signaling mediates aggressiveness and differentiation in neuroblastoma tumors

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By María A. Gómez-Muñoz, Aida Amador-Álvarez, Monica Ojeda-Puertas, Luis Luna-Ramirez
| BioRxiv
Abstract Background: Neuroblastoma (NB) is a pediatric cancer with highly variable outcomes, necessitating improved understanding of the molecular pathways driving its progression. Intratumor cellular heterogeneity related to neural differentiation has emerged as a defining characteristic that can explain its aggressive behavior.
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Analysis of Serial Neuroblastoma PDX Passages in Mice Allows the Identification of New Mediators of Neuroblastoma Aggressiveness

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By Diana Aguilar-Morante, María A. Gómez-Muñoz, Ana Colmenero-Repiso, Aida Amador-Álvarez
| MDPI
Abstract : Neuroblastoma is a neural crest cell-derived pediatric tumor characterized by high inter- and intra-tumor heterogeneity, and by a poor outcome in advanced stages. Patient-derived xenografts (PDXs) have been shown to be useful models for preserving and expanding original patient biopsies in vivo, and for studying neuroblastoma biology in a more physiological setting.
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