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Agrin induces long-term osteochondral regeneration by supporting repair morphogenesis
Augmenting joint regeneration with agrin Injured cartilage can be difficultly repaired and contributes to osteoarthritis progression. Eldridge et al. studied the osteochondral regenerative properties of the proteoglycan agrin. Injecting agrin into the joints of mice with osteochondral defects recruited progenitor cells to the injury site, promoted their differentiation into chondrocytes, and restored the bone-cartilage interface.
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