Aidan Bindoff
Tasmania
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Articles by Aidan Bindoff
Increased synaptic turnover in injured cortical axons: exploring the role of SARM1 ablation
Abstract Introduction: Programmed axon degeneration significantly affects neural connectivity, however, the underlying mechanisms remain poorly understood, particularly in cortical regions. Sterile Alpha and TIR motif-containing protein 1 (SARM1) is a known regulator of axon degeneration in the peripheral nervous system, but its role in cortical axon plasticity, particularly during injury conditions, remains unclear.
Convergent effects of synthetic glucocorticoid dexamethasone and amyloid beta in human olfactory neurosphere‐derived cells
CONFLICT OF INTEREST STATEMENT The authors have no conflicts of interest to declare. Supporting Information Filename Description jnc16263-sup-0001-Supplementaryresults.xlsxExcel 2007 spreadsheet , 8.2 MB Data S1. jnc16263-sup-0002-Supinfo.pdfPDF document, 747.7 KB Data S2. REFERENCES , , , , , , , , , , & (2015). Interaction of peroxiredoxin V with dihydrolipoamide branched chain transacylase E2 (DBT) in mouse kidney under hypoxia. Proteome Science, 13, 4. , , , , , , & (2017).
Hand Motor Dysfunction Is Associated with Both Subjective and Objective Cognitive Impairment across the Dementia Continuum
Executive summary The number of older people, including those living with dementia, is rising, as younger age mortality declines. However, the age-specific incidence of dementia has fallen in many countries, probably because of improvements in education, nutrition, health care, and lifestyle changes.
Family carers of people living with dementia and discussion board engagement in the Understanding Dementia Massive Open Online Course
Abstract Objectives This study compared discussion board involvement between family carers and non-carers in the Understanding Dementia Massive Open Online Course (UD-MOOC). Methods A mixed methods observational cohort study of family carers and non-carers was undertaken over the February-April 2020 UD-MOOC. Discussion board engagement was measured as number of posts and replies and examined longitudinally using mixed models. Discussion topics were explored through structural topic models (STM).
Sex-Specific Protective Effects of Cognitive Reserve on Age-Related Cognitive Decline
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Family carers of people living with dementia and discussion board engagement in the Understanding Dementia Massive Open Online Course
References Alzheimer’s Disease International. (2019). World Alzheimer Report 2019: Attitudes to dementia, London. [Google Scholar] Aneshensel, C. S., Pearlin, L. I., Mullan, J. T., Zarit, S. H., & Whitlatch, C. J. (1995). Profiles in caregiving: The unexpected career. Academic Press. [Google Scholar] Arai, Y., Arai, A., & Zarit, S. H. (2008). What do we know about dementia?: A survey on knowledge about dementia in the general public of Japan. International Journal of Geriatric Psychiatry, 23(4), 433–438.
Consumer Access, Appraisal, and Application of Services and Information for Dementia (CAAASI-Dem): a validation study
• None , & ( ). The aging caregiver in the aged world of dementia . Journal of Systems and Integrative Neuroscience, 3(5), – . • None , , , & ( ). Why caregivers of people with dementia and memory loss don’t use services . Geriatric Psychiatry, 20(6), – . • None , & ( ). All Aspects of Health Literacy Scale (AAHLS): Developing a tool to measure functional, communicative and critical health literacy in primary healthcare settings . Patient Education and Counseling, 90(2), – . • None , , , , , , , and ( ).
Subthreshold repetitive transcranial magnetic stimulation drives structural synaptic plasticity in the young and aged motor cortex
Highlights • Subthreshold rTMS alters dendritic spine density, rate of losses and formation in adult and aged mice. • A single session of subthreshold rTMS induced plasticity for 45hrs following cessation of stimulation. • Multiple sessions of subthreshold rTMS induced plasticity for 21hrs following cessation of stimulation. Abstract Background Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive tool commonly used to drive neural plasticity in the young adult and aged brain.
Studying at university in later life slows cognitive decline: A long‐term prospective study
Abstract Introduction Declining cognition in later life is associated with loss of independence and quality of life. This decline in cognition may potentially be reduced or reversed through engaging in cognitively stimulating activities. This study examined the potential for university attendance in later life to enhance cognitive function in older adults. Methods Cognitively unimpaired adults (n = 485, 69% female, median age 60 years) were given the opportunity to undertake free university study.
Iron is increased in the brains of ageing mice lacking the neurofilament light gene
Loading metrics Open Access Peer-reviewed Research Article James C. Vickers , Anna E. King, Graeme H. McCormack, Aidan D. Bindoff, Paul A. Adlard James C. Vickers, Anna E. King, Graeme H. McCormack, Aidan D. Bindoff, Paul A. Adlard Published: October 23, 2019 https://doi.org/10.1371/journal.pone.0224169 Figures Abstract There has been strong interest in the role of metals in neurodegeneration, and how ageing may predispose the brain to related diseases such as Alzheimer’s disease.
Building dementia knowledge globally through the Understanding Dementia Massive Open Online Course (MOOC)
Abstract The prevalence of dementia is escalating world-wide and knowledge deficits remain a barrier to community inclusiveness and quality care. The need for quality, comprehensive education has been identified as a key priority for global action plans on dementia. The Understanding Dementia Massive Open Online Course (UDMOOC) offers the potential to improve dementia knowledge globally.
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