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Aileen M. Barnes on Muck Rack

Aileen M. Barnes

As seen in: Nature, MDPI
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Articles

Murine model of high bone mass osteogenesis imperfecta exhibits bone matrix hyper-mineralization, misaligned mineral crystals, and altered osteoblast differentiation

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By Aileen M. Barnes, Joseph E. Perosky, Stéphane Blouin, MaryAnn Weis, Alberta Derkyi, Kiersten Campbell, Chris Stephan, David Eyre, Ryan Dale, Peter Fratzl, Nadja Fratzl-Zelman, M. Helen Rajpar, Basma Khoury, Theresa Hefferan, Gali Guterman-Ram, Ghazal Hedjazi, Kenneth M. Kozloff, Joan C. Marini
| Nature Verified
Abstract Osteogenesis imperfecta (OI), characterized by bone fragility and low bone mass, is predominantly caused by mutations in type I collagen. High bone mass OI (HBM OI) is a rare form caused by heterozygous missense mutations at the type I procollagen C-propeptide cleavage site. Knock-in HBM OI mice were generated to elucidate the effect of this mutation on cells and bone.
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CRTAP-Null Osteoblasts Have Increased Proliferation, Protein Secretion, and Skeletal Morphogenesis Gene Expression with Downregulation of Cellular Adhesion

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By Apratim Mitra, Aileen M. Barnes, Marianne M. Knue, Alberta Derkyi
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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