Ailsa R Craven on Muck Rack

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Mapping Plasmodium transitions and interactions in the Anopheles female

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By Elaine O. Cheung, Federico Appetecchia, Sandra March, Ailsa R Craven
| biorxiv.org
Abstract The human malaria parasite, Plasmodium falciparum, relies on Anopheles mosquitoes for transmission. Once ingested during blood feeding, most parasites die in the mosquito midgut lumen or during epithelium traversal. How surviving ookinetes interact with midgut cells and form oocysts is unknown, yet these steps are essential to initiate a remarkable, similarly uncharacterized growth process culminating in the production of thousands of infectious sporozoites.
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