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Aishath S. Naeem on Muck Rack

Aishath S. Naeem

As seen in: Nature
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Articles

Preclinical and clinical efficacy of the HDAC6 inhibitor ricolinostat in combination with BCR pathway inhibitors in relapsed/refractory chronic lymphocytic leukemia

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By Drew Harrison, Bethany Tesar, Yue Ren, Yinglu Zhou, Svitlana Tyekucheva, Stacey Fernandes, John-Hanson Machado, Aishath S. Naeem, Christopher J. Ott, Jennifer Brown, Stephen P. Martindale, Roberta Santos Azevedo, Winnie Nguy, Miranda Stiegler, Valeria Ferre, Vanessa Rai, Binu Kandathilparambil Sasi
| Nature Verified
Dear Editor, Despite the impact of targeted therapies such as BTK and BCL2 inhibitors in chronic lymphocytic leukemia (CLL), drug resistance and relapse remain major challenges, underscoring the need for alternative therapies with unique mechanisms of action [1,2,3,4,5]. Ricolinostat is a potent HDAC6 inhibitor that increases α-tubulin and histone H3 acetylation, the latter via class I HDAC inhibition [6, 7].
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By Stuart Brown, Yanan Zhu, Miriam Moffatt, William O. Cookson, John Harper Verified, Sara Brown, Thomas Reinheckel, Aishath S. Naeem, Cristina Tommasi, Christian Cole, Benjamin Way, Ryan F. L. O’Shaughnessy
| secure.jbs.elsevierhealth.com
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