Ajinkya Limkar on Muck Rack

Ajinkya Limkar

As seen in: Nature, Wiley Online Library
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Articles

Targeting fibrosis in the treatment of lower urinary tract dysfunction

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By Ajinkya Limkar, Sophia M. Vrba, Emily A. Ricke
| Wiley Online Library
Introduction Benign prostatic hyperplasia (BPH) arises from a loss of tissue homeostasis within the prostate and is the leading cause of lower urinary tract dysfunction (LUTD) in aging men [1, 2]. Histological BPH manifests clinically as lower urinary tract symptoms (LUTS), including urinary frequency, urgency, and nocturia. It is estimated that up to 80% of men over the age of 70 years will experience some degree of LUTS [3, 4].
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Antifibrotic therapy for Lower Urinary Tract Symptoms secondary to Benign Prostatic Hyperplasia Original

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By Ajinkya Limkar, Kevin T. McVary, William A. Ricke, Matthew Lee
| Nature
Abstract Lower Urinary Tract Symptoms secondary to Benign Prostatic Hyperplasia (LUTS/BPH) are a ubiquitous condition estimated to affect over 50% of men over the age of 50 years. Various treatment options exist for men presenting with LUTS/BPH, including lifestyle and behavioral modification and medical or surgical treatment. Although multiple medical treatments exist, innovation for the medical treatment of BPH has not significantly progressed.
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