Akancha Pandey on Muck Rack

Akancha Pandey

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Articles

Leveraging mathematical modeling to analyze nonadherence for hydroxyurea therapy in sickle cell disease

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By Rubesh Raja, Jeremie Estepp, Doraiswami Ramkrishna, Akancha Pandey
| Wiley Online Library Verified
Abstract Nonadherence is common in individuals with sickle cell disease (SCD) on hydroxyurea therapy and can be observed with waning improvements in hematologic parameters or biomarkers like mean cell volume and fetal hemoglobin level over time. We modeled the impact of hydroxyurea nonadherence on longitudinal biomarker profiles. We estimated the potential nonadherent days in individuals exhibiting a drop in biomarker levels by modifying the dosing profile using a probabilistic approach.
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