Photo by Michael Zagaris/San Francisco 49ers/Getty Images The 49ers open as 10-point favorites over the Seahawks for their Wild-Card showdown on Saturday afternoon, with the O/U set to 43.5 points on DraftKings SportsBook. The Sportsbooks in Las Vegas expect this to be a 49ers’ win by 27-17. They were the biggest favorites of Wild-Card Weekend when the opening odds were announced, even bigger than the Bills (-9.5) over the Tua Tagovailoa-less Dolphins.